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Magnetic Resonance Imaging of Brain Development in Attention Deficit Hyperactivity Disorder

This study is currently Recruiting

March 2007 By UMC Utrecht

First Recieved on August 31, 2005

Last Updated on March 18, 2007

Sponsor: UMC Utrecht
Collaborators:
Information provided by: UMC Utrecht
Identifier: NCT00143767

Purpose

The primary purpose of this study is to investigate brain whether ADHD represents a disruption or a delay of brain development. Children and adolescents both with and without ADHD are asked to participate in several MRI sessions, two years apart. This will allow us to chart brain development over time, both in typical development and ADHD, and therefore to address whether ADHD represents a disruption or a delay of typical brain development.

Study Type: Observational
Study Design: Observational Model: Case Control, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective

Eligibility

Ages Eligible for Study:6 Years
Genders Eligible for Study:Both
Accepts Healthy Volunteers:Accepts Healthy Volunteers
Criteria

Inclusion Criteria: - Aged 6 - 18 years at initial MRI Inclusion Criteria for Subjects with ADHD: - DSM-IV (APA, 1994) diagnosis of ADHD, according to DISC interview - Scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form(TRF) Inclusion Criteria for Controls: - No DSM-IV (APA, 1994) diagnosis, according to DISC interview - No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF) Exclusion Criteria: - IQ < 70 - Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system - Presence of metal objects in or around the body (pacemaker, dental braces) - History of or present neurological disorder - For individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based

Investigators

  • Investigator: Sarah Durston, Ph.D. - Principal Investigator - Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
  • Investigator: Herman van Engeland, M.D. Ph.D. - Study Chair - Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht

Locations

  • Dept. of Child and Adolescent Psychiatry, UMC Utrecht

    Utrecht, Netherlands

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