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Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

This study is currently Recruiting

April 2011 By Henry Ford Health System

First Recieved on June 3, 2011

Last Updated on June 8, 2011

Sponsor: Henry Ford Health System
Collaborators:
Information provided by: Henry Ford Health System
Identifier: NCT01370460

Purpose

This study aims to assess postoperative blood loss and transfusion rates in total knee replacement after one-time administration of topical tranexamic acid.

Study Type: Interventional
Study Design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Eligibility

Ages Eligible for Study:18 Years
Genders Eligible for Study:Both
Accepts Healthy Volunteers:No
Criteria

Inclusion Criteria: - All adult patients over age eighteen - Primary unilateral total knee arthroplasty at Henry Ford Hospital (Detroit, Michigan, United States) and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan, United States) Exclusion Criteria: - patient history of venous thromboembolic disease or coagulopathy - use of anticoagulant medications within 7 days of surgery - history of arterial embolic disease - history of Class III or IV heart failure - renal failure - intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication (MI, intraoperative fracture, vasopressor support, emergent intubation).

Investigators

  • Investigator: Michael Laker, M.D. - Principal Investigator - Henry Ford Health System

Locations

  • Henry Ford Hospital

    Detroit, Michigan 48202 United States

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