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Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
This study is currently Recruiting
April 2011 By Henry Ford Health System
First Recieved on June 3, 2011
Last Updated on June 8, 2011
This study aims to assess postoperative blood loss and transfusion rates in total knee
replacement after one-time administration of topical tranexamic acid.
||Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
Resources/Links provided by NLM:
|Study Start Date:
|Estimated Primary Completion Date:
Topical tranexamic acid (2g/100mL) applied during unilateral total knee arthroplasty.
100mL 0.9% NS, applied topically
Topical tranexamic acid (2g/100mL 0.9% saline)
100mL 0.9% sterile saline
|Ages Eligible for Study:||18 Years|
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
- All adult patients over age eighteen
- Primary unilateral total knee arthroplasty at Henry Ford Hospital (Detroit, Michigan,
United States) and Henry Ford West Bloomfield Hospital (West Bloomfield, Michigan,
- patient history of venous thromboembolic disease or coagulopathy
- use of anticoagulant medications within 7 days of surgery
- history of arterial embolic disease
- history of Class III or IV heart failure
- renal failure
- intraoperative cardiovascular, pulmonary, orthopaedic, or anesthetic complication
(MI, intraoperative fracture, vasopressor support, emergent intubation).
- Investigator: Michael Laker, M.D. - Principal Investigator - Henry Ford Health System