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Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

This study is currently Recruiting

September 2011 By National Institutes of Health Clinical Center (CC)

First Recieved on November 3, 1999

Last Updated on October 6, 2011

Sponsor: National Institute of Mental Health (NIMH)
Collaborators:
Information provided by: National Institutes of Health Clinical Center (CC)
Identifier: NCT00001246

Purpose

Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain. In this study, researchers will use MRIs to assess brain anatomy and function in normal volunteers and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, multidimensional impairment syndrome, obsessive compulsive disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS), stuttering, Sydenham's chorea, and Tourette's syndrome. Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Study Type: Observational
Study Design: N/A

Eligibility

Ages Eligible for Study:3 Years
Genders Eligible for Study:Both
Accepts Healthy Volunteers:Accepts Healthy Volunteers
Criteria

- Description of study populations: Participants include typically developing subjects, subjects with a variety of neuropsychiatric conditions, and those with anomalous sex chromosome numbers or endocrine conditions. INCLUSION CRITERIA FOR HEALTHY CONTROLS: Subjects consenting to participation in the study Over 3 years of age with no upper limit for age at time of enrollment. EXCLUSION CRITERIA FOR HEALTHY CONTROLS: Presence of any psychiatric disorder in the subject, sibling, or other first-degree relative. Current or past use of psychiatric medication. Special service needs in school. Presence or history of medical conditions known to affect cerebral anatomy. Dental braces. Metal in the body or other contraindications for MRI scanning. For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing. INCLUSION CRITERIA FOR PATIENT POPULATIONS: Male and female subjects over 3 years of age with no upper limit for age (with the exception of the Down syndrome group - see below). Currently meet criteria for at least one of the following: DSM-IV (or other approved) criteria for one of the following clinical diagnoses: Multi-Dimensionally Impaired, Obsessive Compulsive Disorder, Childhood Onset Schizophrenia, Turner Syndrome, Autism Spectrum Disorder, Asperger Syndrome, High Functioning Autism, Pervasive Development Disorder Sex chromosome aneuploidy as determined by karyotype (including XXX, XXXX, XXXXX, XXY, XXYY, XXXY, XXXXY, XYY). ICD-10 criteria for Congenital Adrenal Hyperplasia, Cushings Syndrome, Kallmann Syndrome, and Androgen Insensitivity Syndrome. ADHD Down's Syndrome Newly enrolled adults and minors once they become adults over age 18 who cannot give consent due to limited capacity may have a surrogate, i.e., a legally responsible representative (LAR), sign the consent. LARs include DPA holders, court-appointed legal guardians, or parents or siblings over 18 years of age. We will consult with the Human Subjects Protection Unit as necessary. EXCLUSION CRITERIA FOR ALL PATIENT POPULATIONS: Dental braces. Metal in the body or other contraindications for MRI scanning. For females who have reached menarche: Pregnancy or inability or unwillingness to undergo pregnancy testing. Evidence of another medical condition or traumatic event known to affect cerebral anatomy. A known genetic disorder (other than the condition under investigation) that would be expected to significantly impact findings from cognitive testing and/or neuroimaging. ADDITIONAL INCLUSION CRITERIA FOR ADHD PARTICIPANTS: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)-defined ADHD. The DSM-IV diagnosis of ADHD will be based on the Parent Diagnostic Interview for Children and Adolescents. Conners' Teacher Hyperactivity rating greater than 2 SD above age- and sex-specific means. ADDITIONAL EXCLUSION CRITERIA FOR ADHD PARTICIPANTS: A full-scale IQ of less than 80. Birth before 34 weeks of gestation. Other axis I psychiatric disorder requiring treatment with medication at study entry (with the exception of oppositional-defiant disorder). ADDITIONAL INCLUSION CRITERIA FOR DOWN SYNDROME PARTICIPANTS: Confirmed chromosomal diagnosis of Down syndrome. Age at entry into the study is 30 years or under. ADDITIONAL INCLUSION CRITERIA FOR PARTICIPANTS WITH AUTISM SPECTRUM DISORDERS: Meeting DSM-IV criteria for one of the pervasive developmental disorders (i.e., autistic disorder, Asperger disorder, or pervasive developmental disorder-not otherwise specified). Having a minimum IQ of 70.

Investigators

Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike

    Bethesda, Maryland 20892 United States

Conditions related to this trial:

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