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Immunopathology and Molecular Pathology of Ocular Diseases in Humans
This study is currently Recruiting
October 2011 By National Institutes of Health Clinical Center (CC)
First Recieved on November 3, 1999
Last Updated on November 8, 2011
The purpose of this project is to diagnose and evaluate ocular and related tissues with
various diseases such as conjunctival, corneal, uveal, vitreoretinal and optic nerve
disorders, ocular degenerative, metabolic or genetic diseases and tumors. These will be
studied using light microscopy, electron microscopy, confocal microscopy,
immunohistochemistry, molecular pathological including polymerase chain reaction and in situ
hybridization, as well as measuring the functions of cellular organelles, e.g.,
mitochondrial function. Lymphocytes in the peripheral blood as well as other involved
biopsied tissues and ocular tissue will be compared and categorized by disease. Cytokines,
chemokines or growth factors and/or other released molecules in the blood and ocular fluids
will be also analyzed. Elucidating the relationship between the infiltrating cells, ocular
resident cells, and their products in various diseases will help us to make diagnoses and
increase our understanding of human ocular disorders.
Patients who require eye surgery to treat an eye disease or other disease in which the eye
is involved may participate in this study. Samples of eye tissue and fluid that are
normally removed and discarded during eye surgery will instead be given to researchers for
study. The tissues will be examined under microscope and studied using sophisticated
chemical and biological tests. Immune cells from blood samples may also be examined. These
studies will help better understand and diagnose the various eye diseases and to develop
more attractive therapies.
Resources/Links provided by NLM:
|Study Start Date:
|Estimated Primary Completion Date:
|Ages Eligible for Study:||N/A|
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
- INCLUSION CRITERIA:
1. Participants must be undergoing an eye procedure for clinical care of their
condition which requires the removal of tissue specimens or have agreed
pre-mortem to donate their eyes after death for research purposes.
2. Participants must agree to the de-identified storage of their sample for
potential use in future research projects.
3. For conditions where blood is needed for analysis, participants must consent to
having blood drawn for research evaluation, and be able to safely give a blood
4. Participants must be able to give informed consent for themselves and/or their
minor children who wish to enroll.
1. Participant is unwilling or unable to give informed consent.