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A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12 Monthly Cycles of Single Agent Paclitaxel or Xyotax (CT-2103) (IND# 70177), Versus No Treatment Until Documented Relapse in Women With Advanced Ovarian or Primary Peritoneal or Fallopian Tube Cancer Who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy

This study is currently Recruiting

April 2011 By National Cancer Institute (NCI)

First Recieved on April 18, 2005

Last Updated on April 6, 2011

Sponsor: Gynecologic Oncology Group
Collaborators: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
Identifier: NCT00108745

Purpose

RATIONALE: Drugs used in chemotherapy, such as paclitaxel and polyglutamate paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Paclitaxel and polyglutamate paclitaxel may also stop the growth of ovarian epithelial or peritoneal cancer by blocking blood flow to the tumor. Sometimes, after treatment, the tumor may not need additional treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether paclitaxel is more effective than polyglutamate paclitaxel or observation only in treating ovarian epithelial, peritoneal, or fallopian tube cancer. PURPOSE: This randomized phase III trial is studying paclitaxel to see how well it works compared to polyglutamate paclitaxel or observation only in treating patients with stage III or stage IV ovarian epithelial or peritoneal cancer or fallopian tube cancer.

Study Type: Interventional
Study Design: Allocation: Randomized, Primary Purpose: Treatment

Eligibility

Ages Eligible for Study:N/A
Genders Eligible for Study:Female
Accepts Healthy Volunteers:No
Criteria

DISEASE CHARACTERISTICS: - Histologically confirmed stage III or IV ovarian epithelial or primary peritoneal cancer or fallopian tube cancer - The following histologic epithelial cell types are allowed: - Serous adenocarcinoma - Endometrioid adenocarcinoma - Mucinous adenocarcinoma - Undifferentiated carcinoma - Clear cell adenocarcinoma - Mixed epithelial carcinoma - Transitional cell carcinoma - Malignant Brenner tumor - Adenocarcinoma not otherwise specified - The following histologic cell types are not allowed: - Germ cell tumor - Sex cord-stromal tumor - Carcinosarcoma - Mixed m?llerian tumor or carcinosarcoma - Metastatic carcinoma from other sites to the ovary - Low malignant potential (LMP) tumor (borderline carcinoma), including micropapillary serous carcinoma - Patients with a prior diagnosis of LMP tumor that was surgically resected and who subsequently developed invasive adenocarcinoma are eligible provided patient did not receive prior chemotherapy for the ovarian LMP tumor - Must have undergone surgery for ovarian epithelial or primary peritoneal cancer AND have tissue available for histologic evaluation - Optimal (? 1 cm) residual disease OR suboptimal residual disease after initial surgery - Must have completed at least 5, but no more that 8 courses of primary therapy comprising carboplatin (IV or intraperitoneal) AND paclitaxel or docetaxel-based combination chemotherapy within the past 12 weeks AND have no symptoms of persistent cancer after completion of therapy - CT scan of the abdomen and/or pelvis normal - CA 125 normal - Patients treated with neo-adjuvant platinum-taxane chemotherapy for a presumptive diagnosis of stage III or IV primary peritoneal carcinoma or epithelial ovarian carcinoma (by paracentesis, percutaneous biopsy or open biopsy) are eligible provided the following criteria is met: - Must have undergone interval abdominal surgery after at least one but no more than 6 courses of standard chemotherapy - Surgery must meet the same criteria as the up front surgery, including tissue diagnosis for confirmation of primary tumor site and stage III or IV disease - Patients must have received at least 2 courses after interval abdominal surgery - No synchronous primary endometrial cancer or history of primary endometrial cancer, unless all of the following criteria are met: - Stage ? IB - Less than 3 mm invasion without vascular or lymphatic invasion - No poorly differentiated subtypes, including papillary serous, clear cell, or other FIGO grade 3 lesion PATIENT CHARACTERISTICS: Age - Not specified Performance status - GOG 0-2 Life expectancy - Not specified Hematopoietic - Absolute neutrophil count ? 1,500/mm^3 - Platelet count ? 100,000/mm^3 - No active bleeding Hepatic - Bilirubin ? 1.5 times upper limit of normal (ULN) - SGOT ? 2.5 times ULN - Alkaline phosphatase ? 2.5 times ULN - PT or PTT normal - No acute or chronic hepatitis Renal - Creatinine ? 1.5 times ULN Cardiovascular - Abnormal cardiac conduction (e.g., bundle branch block or heart block) allowed provided the disease has remained stable within the past 6 months - No unstable angina - No myocardial infarction within the past 6 months Other - No neuropathy (sensory and motor) ? grade 2 - No active infection requiring antibiotics - No ongoing gastrointestinal bleeding requiring blood product support - No circumstance that would preclude study participation - No other invasive malignancy within the past 5 years except nonmelanoma skin cancer - Not pregnant or nursing - Fertile patients must agree to use an effective contraception method - Negative pregnancy test PRIOR CONCURRENT THERAPY: Biologic therapy - No prior biologic therapy (e.g., bevacizumab or erlotinib) for any other abdominal or pelvic tumor Chemotherapy - See Disease Characteristics - No prior polyglutamate paclitaxel - No prior chemotherapy for any other abdominal or pelvic tumor - More than 3 years since prior adjuvant chemotherapy for localized breast cancer AND no recurrent or metastatic disease Endocrine therapy - Not specified Radiotherapy - No prior radiotherapy to any portion of the abdominal cavity or pelvis - More than 3 years since prior radiotherapy for localized cancer of the breast, head and neck, or skin AND no recurrent or metastatic disease Surgery - See Disease Characteristics Other - No prior investigational therapy for any other abdominal or pelvic tumor - No prior anticancer therapy that would preclude study therapy - No concurrent amifostine or other protective agents

Investigators

  • Investigator: Maurie Markman, MD - Study Chair - M.D. Anderson Cancer Center
  • Investigator: Robert A. Burger, MD - - Chao Family Comprehensive Cancer Center

Locations

  • UAB Comprehensive Cancer Center

    Birmingham, Alabama 35294 United States

  • Mayo Clinic Scottsdale

    Scottsdale, Arizona 85259-5499 United States

  • Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

    Little Rock, Arkansas 72205 United States

  • Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center

    Burbank, California 91505 United States

  • Rebecca and John Moores UCSD Cancer Center

    La Jolla, California 92093-0658 United States

  • Todd Cancer Institute at Long Beach Memorial Medical Center

    Long Beach, California 90806 United States

  • Jonsson Comprehensive Cancer Center at UCLA

    Los Angeles, California 90095-1781 United States

  • Kaiser Permanente Medical Center - Los Angeles

    Los Angeles, California 90027 United States

  • Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center

    Los Angeles, California 90048 United States

  • Palo Alto Medical Foundation

    Mountain View, California 94040 United States

  • University of California Davis Cancer Center

    Sacramento, California 95817 United States

  • UCSF Helen Diller Family Comprehensive Cancer Center

    San Francisco, California 94115 United States

  • University of Colorado Cancer Center at UC Health Sciences Center

    Aurora, Colorado 80045 United States

  • Boulder Community Hospital

    Boulder, Colorado 80301-9019 United States

  • Penrose Cancer Center at Penrose Hospital

    Colorado Springs, Colorado 80933 United States

  • CCOP - Colorado Cancer Research Program

    Denver, Colorado 80224-2522 United States

  • St. Joseph Hospital

    Denver, Colorado 80218 United States

  • Porter Adventist Hospital

    Denver, Colorado 80210 United States

  • Rose Medical Center

    Denver, Colorado 80220 United States

  • Rocky Mountain Gynecologic Oncology

    Englewood, Colorado 80110 United States

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502 United States

  • North Colorado Medical Center

    Greeley, Colorado 80631 United States

  • Exempla Lutheran Medical Center

    Wheat Ridge, Colorado 80033 United States

  • Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center

    Farmington, Connecticut 06360-2875 United States

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105 United States

  • George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

    New Britain, Connecticut 06050 United States

  • Tunnell Cancer Center at Beebe Medical Center

    Lewes, Delaware 19958 United States

  • CCOP - Christiana Care Health Services

    Newark, Delaware 19713 United States

  • Walter Reed Army Medical Center

    Washington, District of Columbia 20307-5001 United States

  • Morton Plant Hospital

    Clearwater, Florida 33756 United States

  • Florida Gynecologic Oncology - Fort Myers

    Fort Myers, Florida 33905 United States

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224 United States

  • M.D. Anderson Cancer Center at Orlando

    Orlando, Florida 32806 United States

  • Florida Hospital Cancer Institute at Florida Hospital Orlando

    Orlando, Florida 32803-1273 United States

  • Women's Cancer Associates

    Saint Petersburg, Florida 33701 United States

  • Sarasota Memorial Hospital

    Sarasota, Florida 34239 United States

  • H. Lee Moffitt Cancer Center and Research Institute at University of South Florida

    Tampa, Florida 33612-9497 United States

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501 United States

  • Central Georgia Gynecologic Oncology

    Macon, Georgia 31201 United States

  • Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center

    Savannah, Georgia 31403-3089 United States

  • Rush University Medical Center

    Chicago, Illinois 60612 United States

  • Robert H. Lurie Comprehensive Cancer Center at Northwestern University

    Chicago, Illinois 60611-3013 United States

  • Decatur Memorial Hospital Cancer Care Institute

    Decatur, Illinois 62526 United States

  • Gynecologic Oncology

    Hinsdale, Illinois 60521 United States

  • Advocate Lutheran General Cancer Care Center

    Park Ridge, Illinois 60068-1174 United States

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001 United States

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801 United States

  • Central Dupage Cancer Center

    Warrenville, Illinois 60555 United States

  • Elkhart General Hospital

    Elkhart, Indiana 46515 United States

  • Michiana Hematology-Oncology, PC - Elkhart

    Elkhart, Indiana 46514 United States

  • Indiana University Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202-5289 United States

  • Gynecologic Oncology of Indiana

    Indianapolis, Indiana 46237 United States

  • Howard Community Hospital

    Kokomo, Indiana 46904 United States

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350 United States

  • Saint Joseph Regional Medical Center

    Mishawaka, Indiana 46545-1470 United States

  • Michiana Hematology-Oncology, PC - South Bend

    Mishawaka, Indiana 46545-1470 United States

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601 United States

  • South Bend Clinic

    South Bend, Indiana 46617 United States

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601 United States

  • Michiana Hematology Oncology PC - La Porte

    Westville, Indiana 46391 United States

  • CCOP - Iowa Oncology Research Association

    Des Moines, Iowa 50309 United States

  • Medical Oncology and Hematology Associates at Mercy Cancer Center

    Des Moines, Iowa 50314 United States

  • John Stoddard Cancer Center at Iowa Lutheran Hospital

    Des Moines, Iowa 50316 United States

  • John Stoddard Cancer Center at Iowa Methodist Medical Center

    Des Moines, Iowa 50309 United States

  • Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Des Moines, Iowa 50309 United States

  • Mercy Cancer Center at Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314 United States

  • Holden Comprehensive Cancer Center at University of Iowa

    Iowa City, Iowa 52242-1002 United States

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720 United States

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801 United States

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042 United States

  • Cancer Center of Kansas - Fort Scott

    Fort Scott, Kansas 66701 United States

  • Cancer Center of Kansas-Independence

    Independence, Kansas 67301 United States

  • Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

    Kansas City, Kansas 66160-7357 United States

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068 United States

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114 United States

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357 United States

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124 United States

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67401 United States

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152 United States

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208 United States

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214 United States

  • CCOP - Wichita

    Wichita, Kansas 67214 United States

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214 United States

  • Associates in Womens Health, PA - North Review

    Wichita, Kansas 67208 United States

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156 United States

  • Lucille P. Markey Cancer Center at University of Kentucky

    Lexington, Kentucky 40536-0093 United States

  • Central Baptist Hospital

    Lexington, Kentucky 40503-9985 United States

  • Louisville Oncology at Norton Cancer Institute - Louisville

    Louisville, Kentucky 40202 United States

  • Christus Schumpert Cancer Treatment Center

    Shreveport, Louisiana 71101 United States

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932 United States

  • Greater Baltimore Medical Center Cancer Center

    Baltimore, Maryland 21204 United States

  • Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center

    Baltimore, Maryland 21237 United States

  • Union Hospital of Cecil County

    Elkton MD, Maryland 21921 United States

  • Tufts Medical Center Cancer Center

    Boston, Massachusetts 02111 United States

  • Baystate Regional Cancer Program at D'Amour Center for Cancer Care

    Springfield, Massachusetts 01199 United States

  • University of Michigan Comprehensive Cancer Center

    Ann Arbor, Michigan 48109-0942 United States

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995 United States

  • Josephine Ford Cancer Center at Henry Ford Hospital

    Detroit, Michigan 48202 United States

  • Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan 48201-1379 United States

  • CCOP - Grand Rapids

    Grand Rapids, Michigan 49503 United States

  • Gynecologic Oncology of West Michigan

    Grand Rapids, Michigan 49546 United States

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007 United States

  • Borgess Medical Center

    Kalamazoo, Michigan 49001 United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731 United States

  • Michiana Hematology Oncology PC - Niles

    Niles, Michigan 49120 United States

  • William Beaumont Hospital - Royal Oak Campus

    Royal Oak, Michigan 48073 United States

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085 United States

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337 United States

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433 United States

  • St. Luke's Hospital Cancer Care Center

    Duluth, Minnesota 55805 United States

  • Fairview Southdale Hospital

    Edina, Minnesota 55435 United States

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432 United States

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109 United States

  • Masonic Cancer Center at University of Minnesota

    Minneapolis, Minnesota 55455 United States

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407 United States

  • Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900 United States

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905 United States

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416 United States

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416 United States

  • United Hospital

    Saint Paul, Minnesota 55102 United States

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101 United States

  • Ridgeview Medical Center

    Waconia, Minnesota 55387 United States

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125 United States

  • St. Dominic Cancer Center

    Jackson, Mississippi 39216 United States

  • University of Mississippi Cancer Clinic

    Jackson, Mississippi 39216 United States

  • Regional Cancer Center at Singing River Hospital

    Pascagoula, Mississippi 39581 United States

  • Ellis Fischel Cancer Center at University of Missouri - Columbia

    Columbia, Missouri 65203 United States

  • Freeman Cancer Institute at Freeman Health System

    Joplin, Missouri 64804 United States

  • Research Medical Center

    Kansas City, Missouri 64132 United States

  • CCOP - Kansas City

    Kansas City, Missouri 64131 United States

  • Saint Louis University Cancer Center

    Saint Louis, Missouri 63110 United States

  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

    Saint Louis, Missouri 63110 United States

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807 United States

  • St. John's Regional Health Center

    Springfield, Missouri 65804 United States

  • Methodist Estabrook Cancer Center

    Omaha, Nebraska 68114 United States

  • UNMC Eppley Cancer Center at the University of Nebraska Medical Center

    Omaha, Nebraska 68198-6805 United States

  • Women's Cancer Center - La Canada

    Las Vegas, Nevada 89169 United States

  • Renown Institute for Cancer at Renown Regional Medical Center

    Reno, Nevada 89502 United States

  • Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756-0002 United States

  • Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

    Marlton, New Jersey 08053 United States

  • Cancer Institute of New Jersey at Cooper - Voorhees

    Voorhees, New Jersey 08043 United States

  • Southwest Gynecologic Oncology Associates, Incorporated

    Albuquerque, New Mexico 87106 United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico 87131-5636 United States

  • SUNY Downstate Medical Center

    Brooklyn, New York 11203 United States

  • Roswell Park Cancer Institute

    Buffalo, New York 14263-0001 United States

  • New York Hospital Medical Center of Queens - Fresh Meadows

    Fresh Meadows, New York 11365 United States

  • Monter Cancer Center of the North Shore-LIJ Health System

    Lake Success, New York 11042 United States

  • Don Monti Comprehensive Cancer Center at North Shore University Hospital

    Manhasset, New York 11030 United States

  • Long Island Jewish Medical Center

    New Hyde Park, New York 11040 United States

  • Mount Sinai Medical Center

    New York, New York 10029 United States

  • Stony Brook University Cancer Center

    Stony Brook, New York 11794-9446 United States

  • SUNY Upstate Medical University Hospital

    Syracuse, New York 13210 United States

  • Hope A Women's Cancer Center

    Asheville, North Carolina 28816 United States

  • Alamance Cancer Center at Alamance Regional Medical Center

    Burlington, North Carolina 27216 United States

  • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

    Chapel Hill, North Carolina 27599-7295 United States

  • Presbyterian Cancer Center at Presbyterian Hospital

    Charlotte, North Carolina 28233-3549 United States

  • Duke Comprehensive Cancer Center

    Durham, North Carolina 27710 United States

  • Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    Greensboro, North Carolina 27403-1198 United States

  • Zimmer Cancer Center at New Hanover Regional Medical Center

    Wilmington, North Carolina 28401 United States

  • Wake Forest University Comprehensive Cancer Center

    Winston-Salem, North Carolina 27157-1096 United States

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307 United States

  • Aultman Cancer Center at Aultman Hospital

    Canton, Ohio 44710-1799 United States

  • Charles M. Barrett Cancer Center at University Hospital

    Cincinnati, Ohio 45267 United States

  • Case Comprehensive Cancer Center

    Cleveland, Ohio 44106-5065 United States

  • MetroHealth Cancer Care Center at MetroHealth Medical Center

    Cleveland, Ohio 44109 United States

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998 United States

  • Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210-1240 United States

  • Oklahoma University Cancer Institute

    Oklahoma City, Oklahoma 73104 United States

  • Cancer Care Associates - Saint Francis Campus

    Tulsa, Oklahoma 74136-1929 United States

  • Knight Cancer Institute at Oregon Health and Science University

    Portland, Oregon 97239-3098 United States

  • Northwest Cancer Specialists at Rose Quarter Cancer Center

    Portland, Oregon 97227 United States

  • Rosenfeld Cancer Center at Abington Memorial Hospital

    Abington, Pennsylvania 19001 United States

  • Abramson Cancer Center of the University of Pennsylvania

    Philadelphia, Pennsylvania 19104-4283 United States

  • Joan Karnell Cancer Center at Pennsylvania Hospital

    Philadelphia, Pennsylvania 19107 United States

  • UPMC Cancer Center at Magee-Womens Hospital

    Pittsburgh, Pennsylvania 15213 United States

  • Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital

    Pittsburgh, Pennsylvania 15224-1791 United States

  • McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

    Reading, Pennsylvania 19612-6052 United States

  • Women and Infants Hospital of Rhode Island

    Providence, Rhode Island 02905 United States

  • CCOP - Upstate Carolina

    Spartanburg, South Carolina 29303 United States

  • Black Hills Obstetrics & Gynecology LLP

    Rapid City, South Dakota 57701 United States

  • Avera Cancer Institute

    Sioux Falls, South Dakota 57105 United States

  • Sanford Cancer Center at Sanford USD Medical Center

    Sioux Falls, South Dakota 57117-5039 United States

  • Chattanooga Gyn-Oncology

    Chattanooga, Tennessee 37403 United States

  • Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

    Dallas, Texas 75390 United States

  • Brooke Army Medical Center

    Fort Sam Houston, Texas 78234-6200 United States

  • University of Texas Medical Branch

    Galveston, Texas 77555-0361 United States

  • Methodist Hospital

    Houston, Texas 77030 United States

  • Lyndon B. Johnson General Hospital

    Houston, Texas 77026-1967 United States

  • M. D. Anderson Cancer Center at University of Texas

    Houston, Texas 77030-4009 United States

  • Fletcher Allen Health Care - University Health Center Campus

    Burlington, Vermont 05401 United States

  • Northern Virginia Pelvic Surgery Associates

    Annandale, Virginia 22003 United States

  • University of Virginia Cancer Center

    Charlottesville, Virginia 22908 United States

  • Virginia Commonwealth University Massey Cancer Center

    Richmond, Virginia 23298-0037 United States

  • Carilion Gynecologic Oncology Associates

    Roanoke, Virginia 24016 United States

  • CCOP - Virginia Mason Research Center

    Seattle, Washington 98101 United States

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington 98109 United States

  • Northwest Hospital and Medical Center

    Seattle, Washington 98133 United States

  • Pacific Gynecology Specialists

    Seattle, Washington 98104 United States

  • Seattle Cancer Care Alliance

    Seattle, Washington 98109-1023 United States

  • Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

    Seattle, Washington 98122-4307 United States

  • University Cancer Center at University of Washington Medical Center

    Seattle, Washington 98195 United States

  • Cancer Care Northwest - Spokane South

    Spokane, Washington 99202 United States

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405 United States

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508 United States

  • University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

    Madison, Wisconsin 53792-6164 United States

  • Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin 53215 United States

  • Vince Lombardi Cancer Clinic - Sheboygan

    Sheboygan, Wisconsin 53081 United States

  • Waukesha Memorial Hospital Regional Cancer Center

    Waukesha, Wisconsin 53188 United States

  • Aurora Women's Pavilion of West Allis Memorial Hospital

    West Allis, Wisconsin 53227 United States

Conditions related to this trial:

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