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Doctoral CRP on Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients

This study is currently Recruiting

October 2011 By International Atomic Energy Agency

First Recieved on July 19, 2005

Last Updated on October 12, 2011

Sponsor: International Atomic Energy Agency
Collaborators:
Information provided by: International Atomic Energy Agency
Identifier: NCT00122746

Purpose

The researchers plan: - To undertake clinical studies of radiotherapy with or without the administration of the chemotherapeutic agent cisplatin, known to be a radiosensitizer; - To perform pre-clinical studies of the radiosensitivity of human fibroblasts and cervical cancer cell lines in culture, with or without the addition of various HIV proteins or protease inhibitors, in order to determine the extent of any cellular radiosensitizing properties of these molecules; - To develop strategies for sensitizing tumour cells to radiation, specifically by down-regulating specific viral proteins that are known to be factors associated with resistance to radiotherapy.

Study Type: Interventional
Study Design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Eligibility

Ages Eligible for Study:18 Years
Genders Eligible for Study:Female
Accepts Healthy Volunteers:No
Criteria

Inclusion Criteria: - Cancer of the cervix - AIDS Exclusion Criteria: - Unable to give informed consent

Investigators

  • Investigator: Eduardo H. Zubizarreta, M.D. - Study Director - International Atomic Energy Agency

Locations

  • Dept. of Atomic Energy, Tata Memorial Centre

    Mumbai, India

  • Johannesburg Hospital

    Johannesburg, South Africa

  • Ocean Road Cancer Institute

    Dar Es Salaam, Tanzania

  • Radiotherapy Centre

    Kampala, Uganda

  • Radiotherapy Centre

    Harare, Zimbabwe

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