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The Use of Glutathione (GSH) for Prevention of Paclitaxel/Carboplatin (TAXOL/CBDCA) Induced Peripheral Neuropathy: A Phase III Randomized, Double-Blind Placebo Controlled Study

This study is currently Recruiting

November 2011 By National Cancer Institute (NCI)

First Recieved on September 16, 2009

Last Updated on November 4, 2011

Sponsor: North Central Cancer Treatment Group
Collaborators: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
Identifier: NCT00979082

Purpose

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemoprotective drugs, such as glutathione, may help prevent peripheral neuropathy caused by paclitaxel and carboplatin. It is not yet known whether glutathione is more effective than a placebo in preventing peripheral neuropathy. PURPOSE: This randomized phase III trial is studying glutathione to see how well it works in preventing peripheral neuropathy caused by paclitaxel and carboplatin in patients with ovarian cancer, fallopian tube cancer, and/or primary peritoneal cancer.

Study Type: Interventional
Study Design: Allocation: Randomized, Masking: Double-Blind, Primary Purpose: Supportive Care

Eligibility

Ages Eligible for Study:18 Years
Genders Eligible for Study:Female
Accepts Healthy Volunteers:No
Criteria

DISEASE CHARACTERISTICS: - Diagnosis of stage III/IV ovarian cancer, fallopian tube cancer, and/or primary peritoneal carcinoma - Scheduled to undergo treatment with paclitaxel at 175 mg/m^2 and carboplatin at area under the curve = 6 every 21 days for 6 courses with or without bevacizumab PATIENT CHARACTERISTICS: - ECOG performance status 0-2 - Life expectancy ? 6 months - WBC ? 3,400/mm^3 - ANC ? 1,500/mm^3 - Platelet count ? 100,000/mm^3 - Hemoglobin > 10.0 g/dL - Creatinine ? 1.5 times upper limit of normal - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective contraception - Able to complete English language questionnaire(s) alone or with assistance - Willing to provide blood specimens as required by the study - No pre-existing history of peripheral neuropathy > grade 1 (NCI CTCAE v4.0) due to any cause (e.g., chemotherapy, diabetes, alcohol, toxin, or heredity) - No other medical conditions that, in the opinion of the treating physician/allied health professional, would make this study unreasonably hazardous for the patient PRIOR CONCURRENT THERAPY: - See Disease Characteristics - No prior paclitaxel or carboplatin other than the current treatment regimen - No other concurrent treatment for the prevention of peripheral neuropathy, including prescription and over-the-counter or herbal therapies

Investigators

  • Investigator: Charles L. Loprinzi, MD - Study Chair - North Central Cancer Treatment Group

Locations

  • Providence Cancer Center at Providence Hospital

    Mobile, Alabama 36608 United States

  • Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

    Fairbanks, Alaska 99701 United States

  • Mayo Clinic Scottsdale

    Scottsdale, Arizona 85259-5499 United States

  • North Bay Cancer Center

    Fairfield, California 94533 United States

  • Cancer Care Associates

    Fresno, California 93720 United States

  • Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

    Orange, California 92868 United States

  • St. Joseph Hospital Regional Cancer Center - Orange

    Orange, California 92868 United States

  • Feather River Hospital Cancer Center

    Paradise, California 95969 United States

  • Sutter Cancer Center at Roseville Medical Center

    Roseville, California 95661 United States

  • Sutter Cancer Center

    Sacramento, California 95816 United States

  • Aurora Presbyterian Hospital

    Aurora, Colorado 80012 United States

  • Boulder Community Hospital

    Boulder, Colorado 80301-9019 United States

  • Penrose Cancer Center at Penrose Hospital

    Colorado Springs, Colorado 80933 United States

  • CCOP - Colorado Cancer Research Program

    Denver, Colorado 80224-2522 United States

  • Porter Adventist Hospital

    Denver, Colorado 80210 United States

  • St. Anthony Central Hospital

    Denver, Colorado 80204 United States

  • Rose Medical Center

    Denver, Colorado 80220 United States

  • Presbyterian - St. Luke's Medical Center

    Denver, Colorado 80218 United States

  • St. Joseph Hospital

    Denver, Colorado 80218 United States

  • Swedish Medical Center

    Englewood, Colorado 80110 United States

  • Front Range Cancer Specialists

    Fort Collins, Colorado 80528 United States

  • Poudre Valley Hospital

    Fort Collins, Colorado 80524 United States

  • St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center

    Grand Junction, Colorado 81502 United States

  • North Colorado Medical Center

    Greeley, Colorado 80631 United States

  • Sky Ridge Medical Center

    Lone Tree, Colorado 80124 United States

  • Hope Cancer Care Center at Longmont United Hospital

    Longmont, Colorado 80501 United States

  • McKee Medical Center

    Loveland, Colorado 80539 United States

  • St. Mary - Corwin Regional Medical Center

    Pueblo, Colorado 81004 United States

  • North Suburban Medical Center

    Thornton, Colorado 80229 United States

  • Exempla Lutheran Medical Center

    Wheat Ridge, Colorado 80033 United States

  • Bendheim Cancer Center at Greenwich Hospital

    Greenwich, Connecticut 06830 United States

  • Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center

    Hartford, Connecticut 06105 United States

  • Herbert D. Kerman Regional Oncology Center - Daytona Beach

    Daytona Beach, Florida 32114 United States

  • Mayo Clinic - Jacksonville

    Jacksonville, Florida 32224 United States

  • Phoebe Cancer Center at Phoebe Putney Memorial Hospital

    Albany, Georgia 31701 United States

  • Saint Joseph's Hospital of Atlanta

    Atlanta, Georgia 30342-1701 United States

  • Piedmont Hospital

    Atlanta, Georgia 30309 United States

  • CCOP - Atlanta Regional

    Atlanta, Georgia 30342 United States

  • Northside Hospital Cancer Center

    Atlanta, Georgia 30342-1611 United States

  • MBCCOP - Medical College of Georgia Cancer Center

    Augusta, Georgia 30912 United States

  • WellStar Cobb Hospital

    Austell, Georgia 30106 United States

  • John B. Amos Cancer Center

    Columbus, Georgia 31904 United States

  • Charles B. Eberhart Cancer Center at DeKalb Medical Center

    Decatur, Georgia 30033 United States

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501 United States

  • Gwinnett Medical Center

    Lawrenceville, Georgia 30045 United States

  • Kennestone Cancer Center at Wellstar Kennestone Hospital

    Marietta, Georgia 30060 United States

  • Southern Regional Medical Center

    Riverdale, Georgia 30274-2600 United States

  • Harbin Clinic Cancer Center - Medical Oncology

    Rome, Georgia 30165 United States

  • Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

    Savannah, Georgia 31405 United States

  • Kapiolani Medical Center at Pali Momi

    Aiea, Hawaii 96701 United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826 United States

  • Cancer Research Center of Hawaii

    Honolulu, Hawaii 96813 United States

  • Queen's Cancer Institute at Queen's Medical Center

    Honolulu, Hawaii 96813 United States

  • Hawaii Medical Center - East

    Honolulu, Hawaii 96817 United States

  • Straub Clinic and Hospital, Incorporated

    Honolulu, Hawaii 96813 United States

  • OnCare Hawaii, Incorporated - Kuakini

    Honolulu, Hawaii 96817 United States

  • OnCare Hawaii, Incorporated - Lusitana

    Honolulu, Hawaii 96813 United States

  • Kauai Medical Clinic

    Lihue, Hawaii 96766 United States

  • Pacific Cancer Institute - Maui

    Wailuku, Hawaii 96793 United States

  • Maui Memorial Medical Center

    Wailuku, Hawaii 96793 United States

  • St. Joseph Medical Center

    Bloomington, Illinois 61701 United States

  • Illinois CancerCare - Bloomington

    Bloomington%, Illinois 61701 United States

  • Illinois CancerCare - Canton

    Canton, Illinois 61520 United States

  • Graham Hospital

    Canton, Illinois 61520 United States

  • Illinois CancerCare - Carthage

    Carthage, Illinois 62321 United States

  • Memorial Hospital

    Carthage, Illinois 62321 United States

  • Resurrection Medical Center

    Chicago, Illinois 60631 United States

  • Decatur Memorial Hospital Cancer Care Institute

    Decatur, Illinois 62526 United States

  • Eureka Community Hospital

    Eureka, Illinois 61530 United States

  • Illinois CancerCare - Eureka

    Eureka, Illinois 61530 United States

  • Galesburg Clinic, PC

    Galesburg, Illinois 61401 United States

  • Illinois CancerCare - Galesburg

    Galesburg, Illinois 61401 United States

  • Ingalls Cancer Care Center at Ingalls Memorial Hospital

    Harvey, Illinois 60426 United States

  • Mason District Hospital

    Havana, Illinois 62644 United States

  • Illinois CancerCare - Havana

    Havana, Illinois 62644 United States

  • Illinois CancerCare - Kewanee Clinic

    Kewanee, Illinois 61443 United States

  • La Grange Memorial Hospital

    La Grange, Illinois 60525 United States

  • McDonough District Hospital

    Macomb, Illinois 61455 United States

  • Illinois CancerCare - Macomb

    Macomb, Illinois 61455 United States

  • Cardinal Bernardin Cancer Center at Loyola University Medical Center

    Maywood, Illinois 60153 United States

  • Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

    Moline, Illinois 61265 United States

  • Moline, Illinois 61265 United States

  • OSF Holy Family Medical Center

    Monmouth, Illinois 61462 United States

  • Illinois CancerCare - Monmouth

    Monmouth, Illinois 61462 United States

  • Illinois CancerCare - Community Cancer Center

    Normal, Illinois 61761 United States

  • BroMenn Regional Medical Center

    Normal, Illinois 61761 United States

  • Community Cancer Center

    Normal, Illinois 61761 United States

  • Community Hospital of Ottawa

    Ottawa, Illinois 61350 United States

  • Oncology Hematology Associates of Central Illinois, PC - Ottawa

    Ottawa, Illinois 61350 United States

  • Illinois CancerCare - Pekin

    Pekin, Illinois 61603 United States

  • Cancer Treatment Center at Pekin Hospital

    Pekin, Illinois 61554 United States

  • OSF St. Francis Medical Center

    Peoria, Illinois 61615-7827 United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois 61636 United States

  • Proctor Hospital

    Peoria, Illinois 61614 United States

  • Oncology Hematology Associates of Central Illinois, PC - Peoria

    Peoria, Illinois 61615 United States

  • CCOP - Illinois Oncology Research Association

    Peoria, Illinois 61615 United States

  • Illinois Valley Community Hospital

    Peru, Illinois 61354 United States

  • Illinois CancerCare - Peru

    Peru, Illinois 61354 United States

  • Illinois CancerCare - Princeton

    Princeton, Illinois 61356 United States

  • Perry Memorial Hospital

    Princeton, Illinois 61356 United States

  • Illinois CancerCare - Spring Valley

    Spring Valley, Illinois 61362 United States

  • Valley Cancer Center

    Spring Valley, Illinois 61362 United States

  • Regional Cancer Center at Memorial Medical Center

    Springfield, Illinois 62781-0001 United States

  • CCOP - Carle Cancer Center

    Urbana, Illinois 61801 United States

  • St. Francis Hospital and Health Centers - Beech Grove Campus

    Beech Grove, Indiana 46107 United States

  • Michiana Hematology-Oncology, PC - Elkhart

    Elkhart, Indiana 46514 United States

  • Elkhart Clinic, LLC

    Elkhart, Indiana 46514-2098 United States

  • Elkhart General Hospital

    Elkhart, Indiana 46515 United States

  • Howard Community Hospital

    Kokomo, Indiana 46904 United States

  • Center for Cancer Therapy at LaPorte Hospital and Health Services

    La Porte, Indiana 46350 United States

  • Clarian Arnett Cancer Care

    Lafayette, Indiana 47904 United States

  • Saint Anthony Memorial Health Centers

    Michigan City, Indiana 46360 United States

  • Michiana Hematology-Oncology, PC - South Bend

    Mishawaka, Indiana 46545-1470 United States

  • Saint Joseph Regional Medical Center

    Mishawaka, Indiana 46545-1470 United States

  • Michiana Hematology Oncology PC - Plymouth

    Plymouth, Indiana 46563 United States

  • Reid Hospital & Health Care Services

    Richmond, Indiana 47374 United States

  • Memorial Hospital of South Bend

    South Bend, Indiana 46601 United States

  • CCOP - Northern Indiana CR Consortium

    South Bend, Indiana 46601 United States

  • South Bend Clinic

    South Bend, Indiana 46617 United States

  • Michiana Hematology Oncology PC - La Porte

    Westville, Indiana 46391 United States

  • McFarland Clinic, PC

    Ames, Iowa 50010 United States

  • Bettendorf, Iowa 52722 United States

  • Hematology Oncology Associates of the Quad Cities

    Bettendorf, Iowa 52722 United States

  • Mercy Regional Cancer Center at Mercy Medical Center

    Cedar Rapids, Iowa 52403 United States

  • Cedar Rapids Oncology Associates

    Cedar Rapids, Iowa 52403 United States

  • Medical Oncology and Hematology Associates - West Des Moines

    Clive, Iowa 50325 United States

  • CCOP - Iowa Oncology Research Association

    Des Moines, Iowa 50309 United States

  • John Stoddard Cancer Center at Iowa Methodist Medical Center

    Des Moines, Iowa 50309 United States

  • John Stoddard Cancer Center at Iowa Lutheran Hospital

    Des Moines, Iowa 50316 United States

  • Medical Oncology and Hematology Associates at John Stoddard Cancer Center

    Des Moines, Iowa 50309 United States

  • Medical Oncology and Hematology Associates at Mercy Cancer Center

    Des Moines, Iowa 50314 United States

  • Mercy Cancer Center at Mercy Medical Center - Des Moines

    Des Moines, Iowa 50314 United States

  • McCreery Cancer Center at Ottumwa Regional

    Ottumwa, Iowa 52501 United States

  • Mercy Medical Center - Sioux City

    Sioux City, Iowa 51102 United States

  • Siouxland Hematology-Oncology Associates, LLP

    Sioux City, Iowa 51101 United States

  • St. Luke's Regional Medical Center

    Sioux City, Iowa 51104 United States

  • Cancer Center of Kansas, PA - Chanute

    Chanute, Kansas 66720 United States

  • Cancer Center of Kansas, PA - Dodge City

    Dodge City, Kansas 67801 United States

  • Cancer Center of Kansas, PA - El Dorado

    El Dorado, Kansas 67042 United States

  • Cancer Center of Kansas - Fort Scott

    Fort Scott, Kansas 66701 United States

  • Cancer Center of Kansas-Independence

    Independence, Kansas 67301 United States

  • Cancer Center of Kansas, PA - Kingman

    Kingman, Kansas 67068 United States

  • Lawrence Memorial Hospital

    Lawrence, Kansas 66044 United States

  • Cancer Center of Kansas, PA - Liberal

    Liberal, Kansas 67901 United States

  • Cancer Center of Kansas, PA - Newton

    Newton, Kansas 67114 United States

  • Cancer Center of Kansas, PA - Parsons

    Parsons, Kansas 67357 United States

  • Cancer Center of Kansas, PA - Pratt

    Pratt, Kansas 67124 United States

  • Cancer Center of Kansas, PA - Salina

    Salina, Kansas 67401 United States

  • Cancer Center of Kansas, PA - Wellington

    Wellington, Kansas 67152 United States

  • Cancer Center of Kansas, PA - Wichita

    Wichita, Kansas 67214 United States

  • Via Christi Cancer Center at Via Christi Regional Medical Center

    Wichita, Kansas 67214 United States

  • Associates in Womens Health, PA - North Review

    Wichita, Kansas 67208 United States

  • CCOP - Wichita

    Wichita, Kansas 67214 United States

  • Cancer Center of Kansas, PA - Medical Arts Tower

    Wichita, Kansas 67208 United States

  • Cancer Center of Kansas, PA - Winfield

    Winfield, Kansas 67156 United States

  • Ochsner Health Center - Bluebonnet

    Baton Rouge, Louisiana 70809 United States

  • Ochsner Health Center - Covington

    Covington, Louisiana 70433 United States

  • Louisiana State University Health Sciences Center - Monroe

    Monroe, Louisiana 71210 United States

  • CCOP - Ochsner

    New Orleans, Louisiana 70121 United States

  • Ochsner Cancer Institute at Ochsner Clinic Foundation

    New Orleans, Louisiana 70121 United States

  • Feist-Weiller Cancer Center at Louisiana State University Health Sciences

    Shreveport, Louisiana 71130-3932 United States

  • Highland Clinic

    Shreveport, Louisiana 71105 United States

  • Harold Alfond Center for Cancer Care

    Augusta, Maine 04330 United States

  • CancerCare of Maine at Eastern Maine Medical Center

    Bangor, Maine 04401 United States

  • Shore Regional Cancer Center at Memorial Hospital - Easton

    Easton, Maryland 21601 United States

  • Saint Joseph Mercy Cancer Center

    Ann Arbor, Michigan 48106-0995 United States

  • CCOP - Michigan Cancer Research Consortium

    Ann Arbor, Michigan 48106 United States

  • Oakwood Cancer Center at Oakwood Hospital and Medical Center

    Dearborn, Michigan 48123-2500 United States

  • Green Bay Oncology, Limited - Escanaba

    Escanaba, Michigan 49431 United States

  • Genesys Hurley Cancer Institute

    Flint, Michigan 48503 United States

  • Hurley Medical Center

    Flint, Michigan 48503 United States

  • Van Elslander Cancer Center at St. John Hospital and Medical Center

    Grosse Pointe Woods, Michigan 48236 United States

  • Dickinson County Healthcare System

    Iron Mountain, Michigan 49801 United States

  • Foote Memorial Hospital

    Jackson, Michigan 49201 United States

  • Borgess Medical Center

    Kalamazoo, Michigan 49001 United States

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007-3731 United States

  • Bronson Methodist Hospital

    Kalamazoo, Michigan 49007 United States

  • Sparrow Regional Cancer Center

    Lansing, Michigan 48912-1811 United States

  • St. Mary Mercy Hospital

    Livonia, Michigan 48154 United States

  • Clemens Regional Medical Center

    Mount Clemens, Michigan 48043 United States

  • Michiana Hematology Oncology PC - Niles

    Niles, Michigan 49120 United States

  • St. Joseph Mercy Oakland

    Pontiac, Michigan 48341-2985 United States

  • Mercy Regional Cancer Center at Mercy Hospital

    Port Huron, Michigan 48060 United States

  • Seton Cancer Institute at Saint Mary's - Saginaw

    Saginaw, Michigan 48601 United States

  • Lakeside Cancer Specialists, PLLC

    Saint Joseph, Michigan 49085 United States

  • Providence Cancer Institute at Providence Hospital - Southfield Campus

    Southfield, Michigan 48075 United States

  • Lakeland Regional Cancer Care Center - St. Joseph

    St. Joseph, Michigan 49085 United States

  • St. John Macomb Hospital

    Warren, Michigan 48093 United States

  • Alexandria, Minnesota 56308 United States

  • Fairview Ridges Hospital

    Burnsville, Minnesota 55337 United States

  • Mercy and Unity Cancer Center at Mercy Hospital

    Coon Rapids, Minnesota 55433 United States

  • CCOP - Duluth

    Duluth, Minnesota 55805 United States

  • Duluth Clinic Cancer Center - Duluth

    Duluth, Minnesota 55805-1983 United States

  • Miller - Dwan Medical Center

    Duluth, Minnesota 55805 United States

  • Fairview Southdale Hospital

    Edina, Minnesota 55435 United States

  • Mercy and Unity Cancer Center at Unity Hospital

    Fridley, Minnesota 55432 United States

  • Hutchinson Area Health Care

    Hutchinson, Minnesota 55350 United States

  • Immanuel St. Joseph's

    Mankato, Minnesota 56002 United States

  • Minnesota Oncology Hematology, PA - Maplewood

    Maplewood, Minnesota 55109 United States

  • HealthEast Cancer Care at St. John's Hospital

    Maplewood, Minnesota 55109 United States

  • Hennepin County Medical Center - Minneapolis

    Minneapolis, Minnesota 55415 United States

  • Veterans Affairs Medical Center - Minneapolis

    Minneapolis, Minnesota 55417 United States

  • Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

    Minneapolis, Minnesota 55407 United States

  • Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center

    Robbinsdale, Minnesota 55422-2900 United States

  • Mayo Clinic Cancer Center

    Rochester, Minnesota 55905 United States

  • CentraCare Clinic - River Campus

    Saint Cloud, Minnesota 56303 United States

  • Coborn Cancer Center

    Saint Cloud, Minnesota 56303 United States

  • CCOP - Metro-Minnesota

    Saint Louis Park, Minnesota 55416 United States

  • Park Nicollet Cancer Center

    Saint Louis Park, Minnesota 55416 United States

  • United Hospital

    Saint Paul, Minnesota 55102 United States

  • St. Francis Cancer Center at St. Francis Medical Center

    Shakopee, Minnesota 55379 United States

  • Regions Hospital Cancer Care Center

    St. Paul, Minnesota 55101 United States

  • Lakeview Hospital

    Stillwater, Minnesota 55082 United States

  • Ridgeview Medical Center

    Waconia, Minnesota 55387 United States

  • Willmar Cancer Center at Rice Memorial Hospital

    Willmar, Minnesota 56201 United States

  • Minnesota Oncology Hematology, PA - Woodbury

    Woodbury, Minnesota 55125 United States

  • CCOP - Cancer Research for the Ozarks

    Springfield, Missouri 65802 United States

  • Hulston Cancer Center at Cox Medical Center South

    Springfield, Missouri 65807 United States

  • St. John's Regional Health Center

    Springfield, Missouri 65804 United States

  • Hematology-Oncology Centers of the Northern Rockies - Billings

    Billings, Montana 59102 United States

  • Billings Clinic - Downtown

    Billings, Montana 59107-7000 United States

  • CCOP - Montana Cancer Consortium

    Billings, Montana 59101 United States

  • St. Vincent Healthcare Cancer Care Services

    Billings, Montana 59101 United States

  • Bozeman Deaconess Cancer Center

    Bozeman, Montana 59715 United States

  • St. James Healthcare Cancer Care

    Butte, Montana 59701 United States

  • Big Sky Oncology

    Great Falls, Montana 59405-5309 United States

  • Great Falls Clinic - Main Facility

    Great Falls, Montana 59405 United States

  • Sletten Cancer Institute at Benefis Healthcare

    Great Falls, Montana 59405 United States

  • Northern Montana Hospital

    Havre, Montana 59501 United States

  • St. Peter's Hospital

    Helena, Montana 59601 United States

  • Glacier Oncology, PLLC

    Kalispell, Montana 59901 United States

  • Kalispell Medical Oncology at KRMC

    Kalispell, Montana 59901 United States

  • Kalispell Regional Medical Center

    Kalispell, Montana 59901 United States

  • Montana Cancer Specialists at Montana Cancer Center

    Missoula, Montana 59807-7877 United States

  • Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

    Missoula, Montana 59807 United States

  • Cancer Resource Center - Lincoln

    Lincoln, Nebraska 68510 United States

  • Alegant Health Cancer Center at Bergan Mercy Medical Center

    Omaha, Nebraska 68124 United States

  • CCOP - Missouri Valley Cancer Consortium

    Omaha, Nebraska 68106 United States

  • Creighton University Medical Center

    Omaha, Nebraska 68131-2197 United States

  • Immanuel Medical Center

    Omaha, Nebraska 68122 United States

  • CCOP - Nevada Cancer Research Foundation

    Las Vegas, Nevada 89106 United States

  • University Medical Center of Southern Nevada

    Las Vegas, Nevada 89102 United States

  • Seacoast Cancer Center at Wentworth - Douglass Hospital

    Dover, New Hampshire 03820 United States

  • Oncology Center at St. Joseph Hospital

    Nashua, New Hampshire 03060 United States

  • Somerset Medical Center

    Somerville, New Jersey 08876 United States

  • Charles R. Wood Cancer Center at Glens Falls Hospital

    Glens Falls, New York 12801 United States

  • Nalitt Cancer Institute at Staten Island University Hospital

    Staten Island, New York 10305 United States

  • Randolph Hospital

    Asheboro, North Carolina 27203-5400 United States

  • Wayne Memorial Hospital, Incorporated

    Goldsboro, North Carolina 27534 United States

  • Moses Cone Regional Cancer Center at Wesley Long Community Hospital

    Greensboro, North Carolina 27403-1198 United States

  • Pardee Memorial Hospital

    Hendersonville, North Carolina 28791 United States

  • Kinston Medical Specialists

    Kinston, North Carolina 28501 United States

  • Annie Penn Cancer Center

    Reidsville, North Carolina 27320 United States

  • Mid Dakota Clinic, PC

    Bismarck, North Dakota 58501 United States

  • Bismarck Cancer Center

    Bismarck, North Dakota 58501 United States

  • Medcenter One Hospital Cancer Care Center

    Bismarck, North Dakota 58501 United States

  • St. Alexius Medical Center Cancer Center

    Bismarck, North Dakota 58502 United States

  • Altru Cancer Center at Altru Hospital

    Grand Forks, North Dakota 58201 United States

  • Trinity CancerCare Center

    Minot, North Dakota 58701 United States

  • McDowell Cancer Center at Akron General Medical Center

    Akron, Ohio 44307 United States

  • Summa Center for Cancer Care at Akron City Hospital

    Akron, Ohio 44309-2090 United States

  • Barberton Citizens Hospital

    Barberton, Ohio 44203 United States

  • Mary Rutan Hospital

    Bellefontaine, Ohio 43311 United States

  • Adena Regional Medical Center

    Chillicothe, Ohio 45601 United States

  • CCOP - Columbus

    Columbus, Ohio 43215 United States

  • Riverside Methodist Hospital Cancer Care

    Columbus, Ohio 43214-3998 United States

  • Grant Medical Center Cancer Care

    Columbus, Ohio 43215 United States

  • Doctors Hospital at Ohio Health

    Columbus, Ohio 43228 United States

  • Mount Carmel Health - West Hospital

    Columbus, Ohio 43222 United States

  • David L. Rike Cancer Center at Miami Valley Hospital

    Dayton, Ohio 45409 United States

  • Grandview Hospital

    Dayton, Ohio 45405 United States

  • Good Samaritan Hospital

    Dayton, Ohio 45406 United States

  • Samaritan North Cancer Care Center

    Dayton, Ohio 45415 United States

  • CCOP - Dayton

    Dayton, Ohio 45420 United States

  • Grady Memorial Hospital

    Delaware, Ohio 43015 United States

  • Blanchard Valley Medical Associates

    Findlay, Ohio 45840 United States

  • Middletown Regional Hospital

    Franklin, Ohio 45005-1066 United States

  • Wayne Hospital

    Greenville, Ohio 45331 United States

  • Charles F. Kettering Memorial Hospital

    Kettering, Ohio 45429 United States

  • Fairfield Medical Center

    Lancaster, Ohio 43130 United States

  • St. Rita's Medical Center

    Lima, Ohio 45801 United States

  • Strecker Cancer Center at Marietta Memorial Hospital

    Marietta, Ohio 45750 United States

  • Knox Community Hospital

    Mount Vernon, Ohio 43050 United States

  • Licking Memorial Cancer Care Program at Licking Memorial Hospital

    Newark, Ohio 43055 United States

  • Community Hospital of Springfield and Clark County

    Springfield, Ohio 45505 United States

  • UVMC Cancer Care Center at Upper Valley Medical Center

    Troy, Ohio 45373-1300 United States

  • Mount Carmel St. Ann's Cancer Center

    Westerville, Ohio 43081 United States

  • Clinton Memorial Hospital

    Wilmington, Ohio 45177 United States

  • United States Air Force Medical Center - Wright-Patterson

    Wright-Patterson Afb, Ohio 45433-5529 United States

  • Ruth G. McMillan Cancer Center at Greene Memorial Hospital

    Xenia, Ohio 45385 United States

  • Genesis - Good Samaritan Hospital

    Zanesville, Ohio 43701 United States

  • Natalie Warren Bryant Cancer Center at St. Francis Hospital

    Tulsa, Oklahoma 74136 United States

  • Rosenfeld Cancer Center at Abington Memorial Hospital

    Abington, Pennsylvania 19001 United States

  • Geisinger Cancer Institute at Geisinger Health

    Danville, Pennsylvania 17822-0001 United States

  • Geisinger Hazleton Cancer Center

    Hazleton, Pennsylvania 18201 United States

  • Cancer Center at Phoenixville Hospital

    Phoenixville, Pennsylvania 19460 United States

  • Guthrie Cancer Center at Guthrie Clinic Sayre

    Sayre, Pennsylvania 18840 United States

  • Geisinger Medical Group - Scenery Park

    State College, Pennsylvania 16801 United States

  • Chester County Hospital

    West Chester, Pennsylvania 19380 United States

  • Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

    Wilkes-Barre, Pennsylvania 18711 United States

  • Roper St. Francis Cancer Center at Roper Hospital

    Charleston, South Carolina 29401 United States

  • Cancer Centers of the Carolinas - Easley

    Easley, South Carolina 29640 United States

  • McLeod Regional Medical Center

    Florence, South Carolina 29501 United States

  • CCOP - Greenville

    Greenville, South Carolina 29615 United States

  • Cancer Centers of the Carolinas - Faris Road

    Greenville, South Carolina 29605 United States

  • Greenville Hospital Cancer Center

    Greenville, South Carolina 29605 United States

  • Cancer Centers of the Carolinas - Grove Commons

    Greenville, South Carolina 29605 United States

  • Self Regional Cancer Center at Self Regional Medical Center

    Greenwood, South Carolina 29646 United States

  • Cancer Centers of the Carolinas - Greer Medical Oncology

    Greer, South Carolina 29650 United States

  • Cancer Centers of the Carolinas - Seneca

    Seneca, South Carolina 29672 United States

  • Cancer Centers of the Carolinas - Spartanburg

    Spartanburg, South Carolina 29307 United States

  • Medical X-Ray Center, PC

    Sioux Falls, South Dakota 57105 United States

  • Sanford Cancer Center at Sanford USD Medical Center

    Sioux Falls, South Dakota 57117-5039 United States

  • Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center

    Kingsport, Tennessee 37662 United States

  • U.T. Medical Center Cancer Institute

    Knoxville, Tennessee 37920-6999 United States

  • Hematology-Oncology Associates of Fredericksburg, Incorporated

    Fredericksburg, Virginia 22408 United States

  • Southwest Virginia Regional Cancer Center at Wellmonth Health

    Norton, Virginia 24273 United States

  • St. Joseph Cancer Center

    Bellingham, Washington 98225 United States

  • Providence Centralia Hospital

    Centralia, Washington 98531-9027 United States

  • St. Francis Hospital

    Federal Way, Washington 98003 United States

  • Cascade Cancer Center at Evergreen Hospital Medical Center

    Kirkland, Washington 98033 United States

  • Providence St. Peter Hospital Regional Cancer Center

    Olympia, Washington 98506-5166 United States

  • Good Samaritan Cancer Center

    Puyallup, Washington 98372 United States

  • Virginia Mason Medical Center

    Seattle, Washington 98101 United States

  • CCOP - Virginia Mason Research Center

    Seattle, Washington 98101 United States

  • Pacific Medical Center

    Seattle, Washington 98104 United States

  • MultiCare Regional Cancer Center at Tacoma General Hospital

    Tacoma, Washington 98405 United States

  • Franciscan Cancer Center at St. Joseph Medical Center

    Tacoma, Washington 98405-3004 United States

  • St. Clare Hospital

    Tacoma, Washington 98499 United States

  • CCOP - Northwest

    Tacoma, Washington 98405 United States

  • Allenmore Hospital

    Tacoma, Washington 98405 United States

  • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

    Yakima, Washington 98902 United States

  • Edwards Comprehensive Cancer Center at Cabell Huntington Hospital

    Huntington, West Virginia 25701 United States

  • Marshfield Clinic - Chippewa Center

    Chippewa Falls, Wisconsin 54729 United States

  • Marshfield Clinic Cancer Care at Regional Cancer Center

    Eau Claire, Wisconsin 54701 United States

  • St. Mary's Hospital Medical Center - Green Bay

    Green Bay, Wisconsin 54303 United States

  • St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54307-3508 United States

  • Green Bay Oncology, Limited at St. Mary's Hospital

    Green Bay, Wisconsin 54303 United States

  • Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

    Green Bay, Wisconsin 54301-3526 United States

  • Gundersen Lutheran Center for Cancer and Blood

    La Crosse, Wisconsin 54601 United States

  • Dean Medical Center - Madison

    Madison, Wisconsin 53717 United States

  • Holy Family Memorial Medical Center Cancer Care Center

    Manitowoc, Wisconsin 54221-1450 United States

  • Bay Area Cancer Care Center at Bay Area Medical Center

    Marinette, Wisconsin 54143 United States

  • Marshfield Clinic - Marshfield Center

    Marshfield, Wisconsin 54449 United States

  • Columbia Saint Mary's Hospital - Ozaukee

    Mequon, Wisconsin 53097 United States

  • Columbia-Saint Mary's Cancer Care Center

    Milwaukee, Wisconsin 53211 United States

  • Marshfield Clinic - Lakeland Center

    Minocqua, Wisconsin 54548 United States

  • Green Bay Oncology, Limited - Oconto Falls

    Oconto Falls, Wisconsin 54154 United States

  • Ministry Medical Group at Saint Mary's Hospital

    Rhinelander, Wisconsin 54501 United States

  • Marshfield Clinic - Indianhead Center

    Rice Lake, Wisconsin 54868 United States

  • St. Nicholas Hospital

    Sheboygan, Wisconsin 53081 United States

  • Marshfield Clinic at Saint Michael's Hospital

    Stevens Point, Wisconsin 54481 United States

  • Green Bay Oncology, Limited - Sturgeon Bay

    Sturgeon Bay, Wisconsin 54235 United States

  • Marshfield Clinic - Weston Center

    Weston, Wisconsin 54476 United States

  • Marshfield Clinic - Wisconsin Rapids Center

    Wisconsin Rapids, Wisconsin 54494 United States

  • Welch Cancer Center at Sheridan Memorial Hospital

    Sheridan, Wyoming 82801 United States

Conditions related to this trial:

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Disclaimer: The list and ratings above are for informational purposes only, and is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. The goal of the information is to provide you with a comprehensive view of all available treatments, but should not be construed to indicate that use of any one treatment is safe, appropriate, or effective for you. Decisions about use of a new treatment, or about a change in your current treatment plan, should be in consultation with your doctor or other healthcare professional.