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A Magnetic Resonance Spectroscopy and fMRI Study of the Effects of Lisdexamfetamine on Bipolar Depression

This study is currently Recruiting

August 2011 By Steward St. Elizabeth's Medical Center of Boston, Inc.

First Recieved on January 14, 2010

Last Updated on August 12, 2011

Sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc.
Collaborators: Shire Pharmaceutical Development
Information provided by: Steward St. Elizabeth's Medical Center of Boston, Inc.
Identifier: NCT01051440


There have been reports that stimulants may be effective for bipolar depression without triggering mania. This study will examine whether lisdexamfetamine can improve depressive symptoms over the course of eight weeks. Lisdexamfetamine is a prodrug stimulant that is currently approved for attention deficit hyperactivity disorder (ADHD). Participants take the study drug or placebo in addition to a mood stabilizer. The study includes functional magnetic resonance imaging and magnetic resonance spectroscopy to determine whether the medication alters the response to affective stimuli or glutamate, glutamine, or GABA levels. Neuropsychological testing is also included to determine whether the study drug improves memory and attention in this population. The primary hypothesis is that lisdexamfetamine is clinically effective in this population. The secondary hypothesis is that it will result in an increased response to affective stimuli and altered neurotransmitter levels in the anterior cingulate cortex.

Study Type: Interventional
Study Design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Ages Eligible for Study:21 Years
Genders Eligible for Study:Both
Accepts Healthy Volunteers:No

Inclusion Criteria: - Aged 21 to 50 years. - Diagnosed with Bipolar Disorder I or II disorder. - Currently in the depressive phase of the illness. - MADRS greater than 15. - Medication regimen (Lamotrigine, Valproate, Lithium, either alone or in combination with atypical antipsychotics, or typical antipsychotics) at stable doses for at least one month. - Has an established residence and phone. - Capable of providing informed consent. Exclusion Criteria: - Met DSM-IV-TR criteria for rapid cycling within the 6 months prior to enrolling in the study. - Meets DSM-IV-TR criteria for Schizophrenia, Schizoaffective disorder, Post-Traumatic Stress disorder, Obsessive-Compulsive disorder, or Eating disorder. Co-morbid anxiety disorders are not a reason for exclusion. - History of psychotic symptoms at any point during the subject's illness. - Met DSM-IV-TR criteria for alcohol or substance (except for nicotine) dependence or abuse within the past 6 months. - Lifetime history of amphetamine abuse or dependence. - Subject has a lifetime history of stimulant-induced mania - History of seizures, including febrile seizures in childhood. - YMRS greater than 8. - History of significant coronary artery disease, angina, untreated or inadequately treated thyroid disease (less than 1 month chemically euthyroid), type I diabetes, autoimmune disease, glaucoma, hypertension, seizures, or other medical condition(s) which in the opinion of the principal investigator is likely to significantly impact the subject's mood or potential response to the study medication. - ECG with significant arrhythmias or conduction abnormalities, which in the opinion of the physician investigator preclude study participation; uncontrolled hypertension (>160/100) or tachycardia (heart rate >110). - Female subjects who are peri or post-menopausal. - Subjects taking Ritalin or other stimulants, theophylline, steroids, atomoxetine, cholinesterase inhibitors, memantine, modafinil, warfarin, anticonvulsants, clonidine, theophylline, MAOIs and pseudoephedrine, or other medications that are likely to significantly interact (either pharmacokinetically or pharmacodynamically) with the subject's mood or Lisdexamfetamine. - Subject regularly (more than 4 days per week) ingests more than four caffeine containing drinks per day. - Pregnancy. - In women of childbearing potential, an unwillingness to avoid pregnancy for the duration of the study. - Active suicidal ideation. - History of homicidal ideation. - Allergy or other clinical condition which prohibits the use of all of the approved mood stabilizers or Lisdexamfetamine. - Metal in the body (e.g. history of working as a sheet metal worker) or pacemaker which is a contra-indication to MRI scanning. - Significant claustrophobia.


  • Investigator: Michael E Henry, MD - Principal Investigator - Steward St. Elizabeth's Medical Center of Boston, Inc.


  • Caritas St. Elizabeth's Medical Center

    Boston, Massachusetts 02135 United States

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