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The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia
This study is currently Recruiting
April 2011 By Taipei Medical University WanFang Hospital
First Recieved on September 28, 2010
Last Updated on April 21, 2011
Candida albicans is the most common and important clinical fungal pathogen. Our previous
surveillance disclosed that fluconazole could induce different morphological changes in
clinical strains. Our current study on C. albicans causing candiuria disclosed that renal
insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of
treatment failure. However, we also found results of E-test drug susceptible test could not
predict outcome. Hence, retrospective analysis of 31 months period, cases that had C.
albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological
study and potential virulent gene analysis.
This study is designed to clarity the clinical meaning of morphological form and virulent
genes on candidemia. To do this study is probably helpful for treatment of candidiasis.
||Observational Model: Case-Only, Time Perspective: Retrospective
Resources/Links provided by NLM:
|Study Start Date:
|Estimated Primary Completion Date:
|Ages Eligible for Study:||18 Years|
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
- 2007 to 2010 medical records
- Cases with candidemmia of Candida albicans with available clinical information in
medical records for analysis.
- Cases with candidemmia of Candida albicans which clinical isolates were preserved.
- Cases were not hospitalized for treatment and data were not available for analysis.
- Investigator: Tsong-Yih Ou - Principal Investigator - Taipei Medical University WanFang Hospital
- Taipei Medical University - WanFang Hospital