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The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

This study is currently Recruiting

April 2011 By Taipei Medical University WanFang Hospital

First Recieved on September 28, 2010

Last Updated on April 21, 2011

Sponsor: Taipei Medical University WanFang Hospital
Collaborators:
Information provided by: Taipei Medical University WanFang Hospital
Identifier: NCT01211041

Purpose

Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C. albicans causing candiuria disclosed that renal insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of treatment failure. However, we also found results of E-test drug susceptible test could not predict outcome. Hence, retrospective analysis of 31 months period, cases that had C. albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological study and potential virulent gene analysis. This study is designed to clarity the clinical meaning of morphological form and virulent genes on candidemia. To do this study is probably helpful for treatment of candidiasis.

Study Type: Observational
Study Design: Observational Model: Case-Only, Time Perspective: Retrospective

Eligibility

Ages Eligible for Study:18 Years
Genders Eligible for Study:Both
Accepts Healthy Volunteers:No
Criteria

Inclusion Criteria: - 2007 to 2010 medical records - Cases with candidemmia of Candida albicans with available clinical information in medical records for analysis. - Cases with candidemmia of Candida albicans which clinical isolates were preserved. Exclusion Criteria: - Cases were not hospitalized for treatment and data were not available for analysis.

Investigators

  • Investigator: Tsong-Yih Ou - Principal Investigator - Taipei Medical University WanFang Hospital

Locations

  • Taipei Medical University - WanFang Hospital

    Taipei, Taiwan

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