Numbness in hands is the lack of sensation or feeling in the fingers or palms of the hands. Numbness in hands may affect either one or both hands. Numbness in hands is often caused by pressure or irritation on a nerve, but it may also be a symptom of a severe problem such as a stroke. Symptoms of numbness in hands can also include a tingling sensation, weakness, a burning feeling, or a sharp pain. Numbness in hands can occur as a result of an injury to the nerves, type 2 diabetes, peripheral neuropathy (damage to the nerves in the hands and feet), vitamin B-12 deficiency, or inflammation of the blood vessels.