Tingling and numbness is a partial or total lack of sensation that can occur in any part of the body. It can be preceded or followed by a tingling sensation that may feel like “pins and needles” or sharp twitches. Often, tingling and numbness strikes the legs, feet, arms, hands, or fingers. Tingling and numbness can be a sign of a health conditions such as diabetes, migraine headaches, multiple sclerosis, stroke, seizures, or carpal tunnel syndrome. Other causes of tingling and numbness include injury to or pressure on a nerve, insufficient blood supply, vitamin or mineral deficiencies, or herpes zoster or shingles infection.